Black cohosh (cimicifuga racemosa) is an herb traditionally used to treat menopausal symptoms. St. John;s wort (hypericum perforatum) is a plant that is often used in the treatment of mild depression. A recent study revealed that women who took both herbs experienced significant improvement in their menopausal symptoms (hot flashes, mood swings). Three-hundred women were randomly assigned to receive either placebo tablets or tablets containing native black cohosh extract and native St. John's Wort extract. At the end of the study, the average Menopause Rating Scale score decreased by 50% in the treatment group and 19.6% in the placebo group. The Hamilton Depression Rating Scale score decreased by 41.8% in the treatment group and 12.7% in the placebo group. There was no difference in the number of side effects reported between the two groups. Black cohosh should not be used in women with a history of or a high risk of breast cancer.